The skin is the largest organ of the human body, and its primary function is to protect the underlying adipose tissue (i.e. body fat), muscle, ligaments and bones. Additionally, the skin is critical for insulation, temperature regulation, sensation and the synthesis of certain vitamins, such as Vitamin D.

 

The endocannabinoid system has been shown to facilitate immunological and nervous system responses throughout the dermatological system in a variety of ways, and deficiencies in the endocannabinoid system could increase the incidence of diseases that affect the skin and underlying tissues. 

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Cannabidiol (CBD) has shown early promise in the adjunctive management of several common dermatological conditions in the reduction of inflammatory response in both animal and clinical studies. As a result, the following dermatological conditions are currently being researched by scientists exploring the link between reported improvements in these conditions after the adjunctive use of CBD, along with standard dermatological care. 

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• Psoriasis is an immune-mediated disease that causes raised, red, scaly patches to appear on the skin. Psoriasis typically affects the outside of the elbows, knees or scalp, though it can appear on any location of the body. Chronic dermatological conditions such as psoriasis may not only be painful but may also contribute to psychological stress. The anti-inflammatory and analgesic or pain relieving properties of CBD may help to reduce symptoms of psoriasis and other dermatological conditions. Further, researchers are currently exploring how CBD may help to regulate the immunological response to psoriasis thereby improving symptoms and reducing anxiety and depression that are associated with this condition. 

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• Diabetic Ulceration is a condition in which reduced blood flow to the legs and feet results in skin tissue breaking down and exposing the layers underneath, ultimately resulting in chronic sores, cellulitis and recurring infection. Diabetic ulcers are a common cause of frequent hospitalizations for people with diabetes. The potential anti-inflammatory and antibacterial properties of CBD may potentiate other potential therapeutic healing options such as hyperbaric oxygen therapy and the management of diabetic ulcerations.  

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• Scleroderma is a systemic autoimmune disorder that manifests as hardening of the skin and tissue causing swelling and/or pain in the muscles and joints. Scleroderma affects cannabinoid (CB) receptors throughout the body and appropriate administration of CBD may help to improve skin elasticity, reduce dermatological flare-ups and relieve discomfort associated with this chronic disorder.

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